Sickle cell anaemia is caused by the substitution of ________.
Valine at the 6th position of the alpha-globin chain by glutamic acid
Glutamic acid at the 6th position of the beta-globin chain by valine
Valine at the 6th position of the beta-globin chain by glutamine
Glycine at the 6th position of the alpha-globin chain by glutamic acid