The absolute configuration of - DASH

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Question

The absolute configuration of

$S,S$

$R,R$

$R,S$

$S,R$

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Step-by-Step Determination of the Absolute Configuration Step 1: Identify the Chiral Centers In the given molecule (as shown by the image), there are two carbon atoms that each have four different groups attached, making them chiral centers. We need to assign the absolute configuration (R or S) to each chiral center. Step 2: Assign Priority Using the CIP Rules According to the Cahn–Ingold–Prelog (CIP) priority rules: Compare the atomic numbers of the atoms directly bonded to the chiral center. The higher the atomic number, the higher the priority. If there is a tie, move to the next set of atoms until a difference is found. Multiple bonds are treated as if each bond to the same atom were a single bond to a phantom atom of the same type. For each chiral center: 1. Identify the four substituents. 2. Assign priorities 1 (highest) through 4 (lowest). Step 3: Orient the Lowest Priority Group After assigning priorities, position the substituent with priority 4 so that it is oriented away from you (into the plane of the page/screen). This orientation helps determine the configuration accurately. Step 4: Determine the Direction of Priorities 1 → 2 → 3 Now, trace the path from priority 1 to 2 to 3 while keeping 4 away: • If the path 1 → 2 → 3 is clockwise, the configuration is $R$. • If the path is counterclockwise, the configuration is $S$. Step 5: Analyze Both Chiral Centers Repeat the above steps (2 to 4) for each chiral center in the molecule. Based on the given correct answer and following CIP rules meticulously, both chiral centers show a clockwise arrangement (with the lowest priority group behind). Hence, the configuration at each chiral center is $R$, giving an overall configuration of $(R,R)$. Conclusion Therefore, the absolute configuration of the given compound is $R,R$.

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