The relative reactivities of acyl compounds towards nucleophilic substitution are in the order of

Question

Acid anhydride > Amide > Ester > Acyl chloride

Acyl chloride > Ester > Acid anhydride > Amide

Acyl chloride > Acid anhydride > Ester > Amide

Ester > Acyl chloride > Amide > Acid anhydride.

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